AREA OF RESEARCH

The Area of research for medical Conditions could be mentioned as: Immunosuppressive Drug Monitoring, Kidney transplant Recipients Monitoring, Quality and Quantity of Life after Kidney transplantation with respect to pharmacotherapy and surgical methods, adrenal cancer, Benign Prostatic Hyperplasia, Bladder Cancer, Erectile Dysfunction, Hematuria, Kidney Cancer, Kidney Stones, pediatric Urology, Prostate Cancer, Prostatitis, Prosthetic Surgery, Urinary Tract Infection, Genito-Urinary Tract Cancers. Pharmacotherapy after Kidney Transplantation: Cyclosporin and tacrolimus could be mentioned as the main immunosuppressive agents that currently prescribed after kidney transplantation within Iranian population. The wide inter- and intra- variability in pharmacokinetics of such drugs require therapeutic monitoring of concentration. Trough level could be imagined as a surrogate of drug behavior after prescription. Proper linguine for prescription of these drugs should be provided by consideration of drugs behavior in respect to its absorption and elimination by considering the important role of cytochrom P450 in the metabolism phase.

 

 

The honor of Isfahan transplantation research connects to expert team. The performance of investigation enthused by clinical study and encouraged by compassionate and generous support

For advanced planning related to health issues for hospitalized patients, genitourinary tract disorders in a large, representative sample of patients' population in a referral teaching hospital in Isfahan, Iran were ranked. In this retrospective study, 3721 patients (from the year 2013 to 2015) of both genders with a mean age of 45 (ranged from 1 to 93) years old enrolled. Results confirmed that 79% of total population were males and in the 58% age ranged from 20 to 60 years old that was correlated to employed years of life. In the 78% complications related to genitourinary tract disorders ranked as: urolithiasis (n = 27%), prostate (n = 17%), kidney (n = 14%), testis (n = 11%) and bladder (n = 9%). In the residual 22% of population classified disorders were as: penis, urethral stricture, inguinal hernia, vesicoureteral reflux, urinary incontinence, cystocele, renal colic and adrenal gland. In the 528 patients classified kidney disorders were ranked as: ESRD (51%), unknown kidney disease (38%), malignant neoplasm (7%), and cystic kidney (6%). Testis disorders classified as varicocele (40%), testicular torsion (23%), cryptorchidism (16%), and hydrocele (10%). This study confirmed that among a group of genitourinary tract disorders, the frequency of urolithiasis and prostate were higher than others. The percentage of males with genitourinary tract disorders was higher than females. Among testis disorders varicocele and testicular torsion was high. In the more than of half studied patients’ age was related to active and working years of lifetime. Further study toward urolithiasis, prostate disorders, kidney-heart-liver transplantation, preservation time, pretransplant respiratory or peripheral vascular disease in Isfahan/Iran seems to be advantageous.

Immunosuppressive Drug Monitoring

Cytochrome P450 (CYP3A) enzymes are basic for the metabolism of several medications such as tacrolimus, as immunosuppression with tacrolimus in men prevents allograft rejection and reverses steroid-resistant rejection in transplanted recipients. According to a recent publication, more than 100 000 solid organ transplantations are performed every year worldwide. In spite of rapid development associated with the detection of tacrolimus concentrations after organ transplantation, differentiation between the amount of parent drug and drug metabolites seems to be a big challenge. It is well known that tacrolimus metabolic transformations mainly include hydroxylations and demethylations catalysed mostly by members of the cytochrome P450 (CYP) 3A family of haemoproteins. Cytochrome P3A (CYP3A) is the most abundant CYP in human liver, but is also present in high concentrations in enterocytes and in kidney. CYP3A4 activity may vary 4 - 5 fold in human liver (but doses of tacrolimus may vary 14-fold in stable liver recipients reflecting genetic and environmental modulation of enzyme activities in both liver and intestine and contributions from other enzymes. It seems that a higher concentration of metabolite 3 (M-III) may have a nephrotoxic or myelotoxic effect and result in higher frequency of infections.

Research Performed at the IKTRC

 

 

1) Preliminary study of prevalence for bladder cancer in Isfahan Province, Iran

Arab Journal of Urology

 

2018

 

2) Frequency of genito-urinary tract disorders in a tertiary hospital in Isfahan, Iran

American Journal of Experimental and Clinical Research 5 (1), 258-262

 

2018

 

3) Investigation of urinary neutrophil gelatinase associated lipocalin (NGAL) for early diagnosis of acute kidney injury after percutaneous nephrolithotomy

African Journal of Urology 23 (3), 214-218

 

2017

 

4) Review of Iranian instruction programs for clinical pharmacy

American Journal of Experimental and Clinical Research 4 (2), 202-205

 

2017

 

5) Atlas of Death for the Main Causes of Neurologic Disorders in a Local Hospital in Isfahan/Iran

Focus on Sciences 3 (1)

 

2017

 

6) Spirituality Believing in End Stage Diseases Such as; Genito-Urinary Cancers, Multiple Sclerosis, Recipients of Liver, Kidney or Heart Transplantations

Focus on Sciences 3 (1)

 

2017

 

7) Approach to pharmacotherapy of botulinum toxin A in the field of urology

American Journal of Experimental and Clinical Research 4 (1), 189-193

 

2017

 

8) Evaluation of Supportive Psychosocial Protocol on Anxiety of the Patients’ Families’ Located at the Al-Zahra/Isfahan Intensive Care Unit in 2011

Focus on Sciences 3 (3)

 

2017

 

9) The effect of electronic education on knowledge of patients with multiple sclerosis

Journal of education and health promotion 6

 

2017

 

10) Tissue plasminogen activator; identifying major barriers related to intravenous injection in ischemic acute cerebral infraction

Journal of research in medical sciences: the official journal of Isfahan …

 

2017

 

11) A Review on Clinical Pharmacokinetics of Tamsulosin in Patients with Benign Prostatic Hyperplasia

Jundishapur Journal of Chronic Disease Care 6 (1)

1

2017

 

12) Analysis of carbamazepine side effects associated with bone metabolism, folate and vitamin B12 serum levels in Isfahan epileptic patients

American Journal of Experimental and Clinical Research 3 (3), 175-179

 

2016

 

13) Investigation of final causes of death in 5360 deceased patients within a teaching hospital in Isfahan, Iran

American Journal of Experimental and Clinical Research 3 (2), 161-164

 

2016

 

14) Types of dizziness and its relationship with psychological symptoms in patients with chronic dizziness

American Journal of Experimental and Clinical Research 3 (1), 141-145

 

2016

 

15) Clinical Investigation of Levisticum officinale (Lovage) Effectiveness' in Patients with Cystinuria

Journal of Urology and Research 3 (6), 1071-75

 

2016

 

16) Investigation of prostate disorders in 614 patients attended Alzahra urology ward between the years 2013 to 2015 in Isfahan

Int J Pharm Clin Res 8, 1543-1547

 

2016

 

17) Pharmacotherapy updates of recombinant tissue plasminogen activator (r-TPA) in acute ischemic stroke

Jentashapir Journal of Health Research 7 (3)

 

2016

 

18) Efficacy and toxicity of rituximab in multiple sclerosis

Archives of Neuroscience 3 (1)

 

2016

 

19) Fingolimod for multiple sclerosis; mechanism of action, safety and toxicity

Archives of Neuroscience 3 (3)

 

2016

 

20) Review of Warfarin; A Cytochrome P450 Metabolizing Drug, in Clinical Practice

Jentashapir Journal of Health Research 7 (3)

 
 

 

21) Levetiracetam (Keppra): Evidence-Based Polypharmacy in Two Patients With Epilepsy

Jundishapur Journal of Chronic Disease Care 5 (2)

 

2016

22) Prograf Concentrations in Liver Transplantation: Correlation With Headache and Other Neurotoxic Complications?

Thrita 5 (1)

 
 

 

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